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Retatrutide exhibits a prolonged circulating half-life of approximately 150180 hours, enabling sustained multi-receptor engagement

This means it mimics the natural hormone GLP-1, which helps regulate insulin release, blood sugar levels, appetite, and digestion

Weight Regain After Discontinuation All GLP-1 medications show substantial weight regain when stopped

doi: 10.1038/s41569-023-00849-3, PMID: [DOI] [PubMed] [Google Scholar] 9

Programme data have reported, for example, higher mean weight loss at 72 weeks with a GIP/GLP-1 regimen than with some GLP-1-only arms at different time pointscontext, population, and rescue/adherence rules all matter