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Both medications enhanced insulin secretion and reduced appetite, but tirzepatides dual action on GIP and GLP-1 pathways provides broader metabolic benefits including improved lipid profiles, blood pressure, and biomarkers of insulin sensitivity

It is worth noting that UK and European medicines regulators (MHRA and EMA) continue to monitor reports of neuropsychiatric events with GLP-1 receptor agonists through their pharmacovigilance systems, but no causal association has been established at this time
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