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Although not contraindicated, clinicians should closely monitor thyroid function tests and adjust therapy as weight and metabolic status evolve under GLP-1RA treatment [65]

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The prevention of diabetes is an urgent issue

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Tongzhi Wu, Adelaide Medical School, The University of Adelaide, Adelaide, SA 5000, Australia

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This clinical trial did not include patients with T2D, and the emerging data suggests that the weight-loss effects of tirzepatide are reduced in patients with diabetes, a difference also observed in trials with 2.4 mg of semaglutide 2

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Available online at: (cited March 17, 2025)

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Decision Support Tool: Features to Consider in Determining if a Clinical Trial is Phase II or Phase III

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