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Nausea: 50-66% Diarrhea: 49% Vomiting: 41% Dyspepsia: Elevated risk Discontinuation due to side effects: 15.9-20% The higher side effect rates for Survodutide require context

This ambiguity creates risk for researchers

At 48 weeks, the least-squares mean percentage change in body weight was -8.7% in the 1 mg group, -17.1% in the combined 4 mg group, -22.8% in the combined 8 mg group, and -24.2% in the 12 mg group, compared with -2.1% in the placebo group

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Concurrently, in insulin-resistant states, increased circulating levels of insulin stimulate hepatic lipogenic enzymes and increase de novo hepatic lipogenesis, exacerbating hepatic steatosis, inflammation, and fibrosis [6, 12]

Together, these data make retatrutide relevant for research on hepatic substrate flux, adipose-liver crosstalk, and integrated lipid metabolism [5][7][8]