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In Vivo Assessment of Drug Interactions Effects of Sitagliptin on Other Drugs In clinical studies, sitagliptin did not meaningfully alter the pharmacokinetics of metformin, glyburide, simvastatin, rosiglitazone, digoxin, warfarin, or an oral contraceptive (ethinyl estradiol and norethindrone) (Table 4), providing in vivo evidence of a low propensity for causing drug interactions with substrates of CYP3A4, CYP2C8, CYP2C9, P-gp, and organic cationic transporter (OCT)

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But its important to manage your diabetes during pregnancy to avoid the risk of problems with fetal development (commonly called birth defects)

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The exclusion criteria were the presence of diabetes mellitus, serious chronic diseases, the intake of drugs with any effect on body weight, glucose metabolism, pain and edema

This helps identify contributing factors and allows your provider to determine whether GLP-1 therapy may be appropriate for your goals