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Dose adjustments of these medications may be required when starting GLP-1 therapy, regardless of timing

The aim of this review was to summarize the recent updates from both clinical trials and preclinical experiments on the impact of GLP-1 receptor agonists (GLP-1RAs) and DPP-4 inhibitors (DPP-4i) on cardiovascular outcomes

The findings underscore that GLP-1 response is a polygenic trait influenced by both common and rare loci, and that integrating pharmacogenomics with functional analyses may advance precision medicine in type 2 diabetes

The theory also suggests that a persons weight set point is established early in life and remains relatively stable unless altered by specific conditions, explaining why weight loss is often difficult to maintain

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These symptoms typically diminish over time with gradual dose escalation