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It can be used alone or in combination with other diabetes medication(s)

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Graphical abstract INTRODUCTION 1 , 2 The multifaceted mechanisms of action of GLP-1 RAs collectively improve glycemic control and promote weight loss, making them increasingly popular in the treatment of metabolic diseases such as type II diabetes mellitus (DM II) and obesity

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As a PAM, compound 2 caused a concentration-dependent increase in the affinity of GLP-1 and oxyntomodulin 31 and induced biased signaling in a probe-dependent manner 31,32