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Writing original draft: Imane Benabbad, Petter Bjornstad, Mathijs C

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Although available interventions act through diverse molecular and functional mechanisms, they share the overarching goal of achieving clinically meaningful and sustained weight loss, ultimately aiming to reduce obesity-related metabolic and cardiovascular complications (Table 1) [98]

Furthermore, the observational design of the study contributes to the lack of detailed information on underlying patient conditions and hinders the establishment of a causal relationship between GLP-1 receptor agonists and adverse psychiatric effects