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7 In particular, weight loss induced by GLP-1 RAs has been associated with significant improvement in debilitating headaches, especially in conditions such as idiopathic intracranial hypertension (IIH) and migraine, both of which are known to be exacerbated by obesity and its associated systemic inflammation

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Reduced glutamate receptors, presynaptic neurotransmitter proteins, and postsynaptic functional proteins in the PFC and hippocampus were also observed ( Figure 2 ) (Zhao et al., 2012