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Second, the psychological symptoms of depression improved in both studies to a greater extent than the neurovegetative symptoms (e.g., sleep and appetite disturbances)

Its always important to set realistic expectations, as results are not guaranteed

The key mechanistic distinction is GIPR engagement: retatrutide adds GIP receptor agonism to the GLP-1R/GCGR dual mechanism, which published investigational data associate with enhanced adipose signalling and weight loss outcomes

Some retain residual OSA and stay on combination therapy

Informed consent was obtained from all participants before enrollment and throughout the study

What makes GLP-1s so special