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Probably more than once

The body's metabolic system is a complex, resilient, and deeply entrenched network of signals

In a follow-up study, a calorie-restricted weight-matched group was introduced alongside the vehicle, GLP-1, MK-801 and GLP-1MK-801 groups (Extended Data Fig

They typically had shorter duration of obesity before treatment

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Preclinical studies suggest that GLP-1RAs have a beneficial effect on major NAFLD histological outcomes, i.e., hepatic steatosis and inflammation, through multiple intrahepatic mechanisms, including increased fatty acid -oxidation, activation of autophagy, suppression of inflammation, and oxidative stress