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Both peptides have been tested in mixed-gender populations

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Cardiorenal syndrome can be categorized as: Type 1 Acute heart failure causing acute kidney injury Type 2 Chronic heart failure causing chronic kidney injury Type 3 Acute kidney injury causing acute heart failure Type 4 Chronic kidney injury causing chronic heart failure Type 5 Co-development of heart and kidney injury by another systemic process

Outcomes were identified using International Classification of Diseases (ICD) diagnostic codes, as detailed in Supplementary Method S1