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Consider the following when managing surgical patients who are taking GLP-1 receptor agonists: Complete a thorough perioperative assessment

Since appetite may decrease, patients need to make every meal count

The recent discovery of anti-inflammatory, immunoregulatory and differentiation properties at the joint tissue and cellular levels of GLP-1 analogues raises the hypothesis of their potential interest to treat OA

If efficacy suddenly decreases or side effects change substantially despite using the same dose, suspect potency issues

Resistance training and higher protein intake can only partially help mitigate these losses

Be extra careful if you already have nausea, vomiting, bloating, constipation, reflux, or stomach discomfort