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In the SURMOUNT-1 trial, tirzepatide 15 mg produced roughly 21% average body-weight reduction over 72 weeks (NEJM 2022)

Most insurance plans do cover the cost of disease treatment and since the FDA approved semaglutide for diabetes, that was the original intent for the medication
This flexibility can lead to improved outcomes, particularly for patients who may require doses outside of Mounjaros fixed options
It can also cause nausea

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