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Patients with higher starting weights often achieve larger absolute weight losses, though percentage reductions tend to cluster in similar ranges across the BMI spectrum

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Then theres also the question of efficacy

These include: Nausea (most common, particularly at higher doses) Vomiting Diarrhoea Constipation Decreased appetite Gastrointestinal events were generally mild to moderate in severity and tended to resolve as participants adapted to each dose level