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Official supply shortages persisted for most of 2024, as surging demand for AOMs continued to outstrip product supply, despite limited reimbursement, which presented an opportunity quickly seized upon by U.S

All of these unanswered questions only add to the urgency of determining who is most likely to benefit from GLP-1s. : Luliia Burmistrova / Getty

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However, the structural complexity and conformational plasticity of class B1 GPCRs make conventional single-method virtual screening approaches prone to bias and limited chemotype recovery