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Altered IRS1 phosphorylation has also been demonstrated in both cross-sectional and longitudinal analysis of neuronal-derived exosomes in AD cases in comparison to matched controls [139, 140]

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Currently, the scientific data on liraglutide dosing stems from clinical trials of Victoza and Saxenda, which have studied the peptide regarding its effects on conditions such as diabetes and obesity

It also relied on the hard toil of multiple players in academic and pharmaceutical laboratories over many years

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Overall, the introduction of the new obesity pharmacotherapies may shift the focus of the multidisciplinary team on nutrition support during the rapid WL phase and on behavioural changes aiming to support long-term weight maintenance, similar to what is the focus after bariatric surgery