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Technical Guidance for Clinical Trials of Drugs for the Treatment of Adults with Type 2 Diabetes (China National Medical Products Administration, 2023)
Alcohol is a diuretic, promoting fluid loss through increased urination

Dysentery Diarrhea Angiodysplasia Ischemic colitis Out of the above causes, hemorrhoids, anal fissures, constipation, diarrhea, and hard stools are commonly seen in daily practice

CALIFORNIA WARNING

Always swirl gently instead

doi: 10.1136/bmjopen-2016-013927 77 ElSayedNAAleppoGArodaVRBannuruRRBrownFMBruemmerDet al