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In another report, a 26week treatment with the GLP1R/GIPR dual agonist LY3298176 (Tirzepatide, Eli Lilly), showed significant reduction in A1c in an incremental, dosedependent manner (4 doses from 1 mg to 15 mg, A1c reduction from 1.06% to 1.94% respectively)

Diabetes Care 44(6):14431446

Finally, an analysis of some of the original trials for the use of semaglutide in weight management (STEP 1, 2, 3 and 5) found no significant increase in depressive symptoms or suicidal ideation/behavior

Therefore, compounded drugs should only be used to meet a patients needs if the patients medical needs cannot be met by an available FDA-approved drug

The comparison is useful for understanding treatment options, but calling Toujeo a GLP-1 would be like calling aspirin an antibiotic because both come in pill form

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