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The sympathetic system provides the fight or flight response, and its effects are mediated through stimulatory neurotransmitters such as norepinephrine and epinephrine

This study also confirmed that activated microglia can activate the NF-B pathway in astrocytes, activate astrocytes, and reduce support for neurons (data not shown)

From that perspective, the FDAs request makes perfect sense

However, spending varies widely by state, reflecting differences in coverage policies and population needs