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However, there is a suggestion that such effects might endure for a more prolonged duration in the case of the shorter-acting twice-daily exenatide (Byetta) 49

Glucagon-like peptide-1 decreases intracerebral glucose content by activating hexokinase and changing glucose clearance during hyper-glycemia

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Preproglucagon neurons projecting from the NTS carry GLP-1 to other areas of the brain that induce satiety including critical areas of the hypothalamus