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Therefore, the interaction between GLP-1R and Cav-1 is necessary not only for receptor trafficking to the cell membrane, but also for activation of the intracellular signaling pathway

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For most patients, GLP-1 receptor agonists like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) require long-term use to maintain their benefits

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Animals were fasted overnight (~1214 hours) before receiving an i.p