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Pharmacological treatment of obesity is associated with post-cessation weight regain or weight cycling a further concern in the context of sarcopenia

A recent study suggests that patients taking semaglutide may increase the risk of developing a rare condition called NAION (non-arteritic anterior ischemic optic neuropathy)

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This phenomenon is associated with uncoupled mitochondrial respiration, elevated proton leak, ROS formation, cellular apoptosis, and, more important, increased myocardial oxygen consumption (56)

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