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Approach to treatment failure in inflammatory bowel disease
For long peptides, such as GLP-1 analogs, deletion and isomeric impurities are generally the most prevalent at the crude stage
Simultaneously, the activity of phosphofructokinase-1 (PFK-1) rises, and the overall glycolytic flux also increases (62)
doi: 10.2337/dc14-1984 [DOI] [PubMed] [Google Scholar] 157
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