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Its likely that GLP-1 RAs (or their combinations) will be part of a future MASH therapy regimen, given weight loss is the cornerstone treatment and GLP-1 causes weight loss plus some direct hepatic fat reduction

Retatrutide is still in clinical development and is not broadly approved as a standard treatment

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42 While the exact mechanisms are not fully understood, imaging studies suggest that reductions in upper airway adiposity, particularly tongue fat, may contribute to these improvements

Moreover, it was also shown that while heat acclimation reduced the response of the brown adipocytes to glucagon, cold acclimation did not modify it [27]

These results prompted the hypothesis on a direct role of GLP-1 in controlling pubertal development through the hypothalamic GnRH secretion, although this mechanism still remains to be unraveled