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Given their vastly different half-lives, their administration schedules would be independent

doi: 10.1074/jbc.M209423200 42 CampbellJEDruckerDJ

Findings from observational data are at higher risk of bias and have less trustworthy results that are inconsistent across different study designs and subgroup analyses

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Separately, GLP-1 RA pretreatment in Abeta142-treated hippocampal primary cell cultures significantly increased phosphorylated CaMKII alpha -positive cells indicating that GLP-1 RAs may have neuroprotective effects through glutamate receptor-mediated responses.Reference Wang, Wang, Jiang, Yuan, Yu and Li 46 Taken together, GLP-1 RAs may have protective effects against neuropathological changes by promoting neurogenesis and synaptic plasticity