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Use With Caution in Research Contexts Because Tirzepatide interacts with GLP-1 and GIP receptor pathways involved in appetite regulation, glucose signaling, digestion, and metabolic function, additional caution may be warranted in research models involving significant metabolic, gastrointestinal, pancreatic, or endocrine-related conditions

49% of Americans and 35% of Britons think GLP-1 prescriptions are more socially acceptable for those earning over $100K a year

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Lixisenatide had the highest risk of inducing vomiting, while dulaglutide had the lowest

These data use agreements do not permit the authors to share patient level source data or data derivatives with individuals and institutions not covered under the data use agreements
