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Agonista del receptor GLP-1 que estimula la secrecin de insulina dependiente de glucosa, suprime el glucagn e inhibe el vaciamiento gstrico

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The human proglucagon amino acid sequence contains 160 amino acids with pancreatic glucagon made up of residues 33-61 and GLP-1 derived from residues 72-108 after further processing ( Figure 1 )

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The challenge with combining retatrutide with other GLP-1-active compounds is receptor overlap