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It's important to note that a higher-dose formulation of semaglutide (2.4mg), marketed as Wegovy, has been specifically licensed for weight management, with clinical trials showing weight loss of approximately 10-15%

Metformin has been used for decades and safety profile is well established

In conclusion, although preclinical evidence strongly supports the neuromodulatory role of GLP-1R signaling in reducing psychostimulant-induced behaviors, further research is required to refine our understanding of sex-specific effects, long-term efficacy, pharmacodynamic targets, and translational applicability

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The trial participants were also not representative of our modern patients for a variety of other reasons

More evidence is needed to clarify the ideal duration that an AOM should be given initially before the first interval, but longer compliance with anti-obesity agents from the outset does result in reduced weight regain following cessation [97]