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5,6,7 GLP-1 is a peptide produced by the cleavage of proglucagon, mainly synthesized in the intestinal mucosal L-cells, pancreatic islet -cells, and neurons in the nucleus of the solitary tract

doi: 10.1111/obr.13296

Chang CH, Lu CH, Chung CH, Su SC, Kuo FC, Liu JS, et al

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Thus, it appears that brain GIP receptor signalling plays a key role in the regulation of energy balance

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