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Lifestyle and environmental adjustments often provide significant relief: Temperature control : Maintain cooler ambient temperatures, use fans, and dress in layers that can be easily removed Breathable fabrics : Choose natural fibres such as cotton and linen that allow better air circulation Trigger avoidance : Identify and minimise exposure to common triggers including spicy foods, caffeine, alcohol, and hot beverages Stress management : Practise relaxation techniques such as deep breathing exercises, meditation, or yoga, as stress can exacerbate vasomotor symptoms Regular exercise : Moderate physical activity may help regulate body temperature and improve overall wellbeing, though intense exercise immediately before bed should be avoided Dietary considerations may also prove beneficial

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The weight loss observed after a short time period seems to be maintained with a long-term diet

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Bringing costs down may finally put them within reach

Treatment regimen estimand This estimand is used to assess the average treatment effect of bimagrumab, semaglutide or bimagrumab plus semaglutide for all randomized participants at week 48, regardless of treatment adherence and/or premature discontinuation of study treatment or placebo