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However, no significant effect was observed in men with overweight or obesity

10.3233/JPD-171068 [DOI] [PMC free article] [PubMed] [Google Scholar] Weina H, Yuhu N, Christian H, Birong L, Feiyu S, Le W (2018) Liraglutide attenuates the depressive- and anxiety-like behaviour in the corticosterone induced depression model via improving hippocampal neural plasticity

These findings align with those of pooled analyses from liraglutide phase 2/3 trials in obesity171 and retrospective case-control studies in T2DM.172 It should be noted, however, that patients in the latter study did not receive high-dose GLP-1RAs approved for obesity and that detecting mental health disorders in routine clinical practice remains challenging

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