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Plasma DPP-4 activity and TG excursion after olive oil administration was reduced, and plasma active GLP-1 was increased to a greater extent after administration of systemically active versus gut-selective doses of sitagliptin in Dpp4 Gut+/+ mice (Figure 4, A and B)

The peptide is best known for its ability to activate AMPK, a key energy-sensing enzyme that boosts fat metabolism, enhances glucose utilization, and improves mitochondrial function

Several DPP-4 inhibitors with distinct structures have been approved for clinical use, including sitagliptin, alogliptin, linagliptin, gemigliptin, anagliptin, and teneligliptin (22) (Appendix 1 in Supplementary File)

2E) in the control group were significantly greater compared with those in the Exe-9-treated group

Any suspected adverse drug reactions should be reported via the MHRA Yellow Card scheme (yellowcard

*In a 64-week medical study of 307 adults living with obesity, or with overweight and at least one weight-related medical problem, along with a reduced-calorie diet and increased physical activity.