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COI Statement Conflict of Interest: Professor Aronne reports receiving grants or personal fees from Eli Lilly and Company and other manufacturers of obesity and diabetes medications and treatments
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Reduced appetite and associated improved insulin sensitivity make the body better at burning off fats

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It reduced the expression of BAX (a pro-apoptotic protein) and increased Bcl-2 (an anti-apoptotic counterpart), lowering the BAX/Bcl-2 ratioan established marker of cell death susceptibility