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L., et al., Cardiovascular, Mortality, and Kidney Outcomes With GLP1 Receptor Agonists in Patients With Type 2 Diabetes: A Systematic Review and MetaAnalysis of Randomised Trials, Lancet Diabetes & Endocrinology 9, no

GLP-1 secretion in response to intraduodenal infusion of glucose increases with somatostatin receptor antagonism (SSTr2 and SSTr5) (Jepsen et al., 2019)

Comparison to Semaglutide: While Semaglutide acts primarily through GLP-1 receptors in the pancreas and brain, Cagrilintide targets amylin receptors in the hindbrain

However, all included studies enrolled adult participants, precluding analyses in pediatric or adolescent populations

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Clinical trials have shown average weight loss of up to 24.2% of total body weight over 48 weeks at the highest dose