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Whether the improvement in these outcomes is secondary to weight loss, or attributable to direct actions of GIPR/GLP1R agonism in key tissues (Figure 4) is currently the focus of ongoing mechanistic studies

Personalized diet plans are a cornerstone of effective weight management therapy, offering a structured approach to achieving and maintaining weight loss goals

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In type 2 diabetes rat models, where bone mass is often reduced, contrary to humans, where bone mass is often normal or increased, liraglutide administration in the range of ~ 110160 nmol/kg/day resulted in increased trabecular BMD and restoration of trabecular microarchitecture parameters in the appendicular and axial skeleton [6367]