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Patience through the first eight weeks pays dividends in tolerability at higher doses

2 Interactions between the GLP-1 pathway and alcohol As shown in Figure 1, the accumulated preclinical findings imply that the GLP-1 pathway modulates alcohol-mediated responses, which include the following: 1) alcohol drinking, 2) alcohol-induced behaviors and neurochemistry, 3) the motivation to consume alcohol and alcohol-seeking, and 4) relapse drinking

Lancet 373 , 17651772 (2009)

The most common adverse effects were nausea, vomiting, and diarrhea during the first 4-8 weeks of treatment

So GLP-1 arent first-line for HF, but they dont harm and do help weight, which is useful

Another major benefit is flexibility in timing