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They advise against taking two doses at the same time to make up for a missed one

It prevents the most common dosing errors

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Characterizing factors associated with differences in FGF19 blood levels and synthesis in patients with primary bile acid diarrhea

99 , E143E148 (2014)

Many of the negative cognitive and mood effects reported anecdotally depression, low energy, difficulty concentrating may not be direct drug effects at all
