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The mechanism underlying heart rate reduction can be attributed to the acetylcholine released by vagal parasympathetic fibers (Loffelholz and Pappano 1985) that innervate the sinoatrial and the atrioventricular nodes, with negative chronotropic and dromotropic effects, respectively (Coote 2013

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Led by Arun Sanyal, M.D., of the Stravitz-Sanyal Institute for Liver Disease and Metabolic Health, and Philip Newsome, Ph.D., of Kings College London, researchers are exploring the potential of semaglutide to treat people with metabolic dysfunction-associated steatohepatitis, or MASH

2021;22(11):e13326

Given that histone modifications and chromatin remodeling represent important epigenetic mechanisms involved in addiction pathophysiology (10, 11), we focused detailed analysis on GO terms related to histone and chromatin processes