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More widespread breast cancer screening and improved treatments have contributed to a more than 40% decline in breast cancer deaths in the past 40 years, said ACR Chief Research Officer Etta D

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Even if GLP-1 levels themselves do not rise substantially, the bodys inflammatory or autonomic response may activate GLP-1like pathways, especially along the gut-brain axis

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Adverse Effects and Long-Term Safety Concerns While GLP-1 receptor agonists have shown significant benefits, their widespread use is limited by potential side effects such as gastrointestinal distress, pancreatitis risk, and concerns over long-term metabolic effects

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8,9,10 Long-term dietary irregularities and metabolic dysfunction caused by obesity have also been demonstrated to increase the prevalence of UC

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Any association is more likely related to underlying conditions such as diabetes

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In the UK, NHS diabetic eye screening guidance has not required extra screening purely because someone starts a GLP-1 or has rapid improvement, but if someone has missed their last screening and is about to start treatment, they can be re-invited on request

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