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Circulation 124 (21), 23382349

In addition to its effects on insulin, GIP plays a crucial role in fat accumulation by promoting the activity of adipocyte-expressed lipoprotein lipase and promoting bone formation by preventing osteoclast apoptosis, as evidenced by the thinner bone trabeculae seen in mice lacking GIP receptors [2022]

80-INSMSU-E01, Alpco), according to the manufacturers instruction

The practice of microdosing GLP-1 medications is mainly experimental and off-label

Cells producing and secreting enteroglucagon were originally identified by immunohistochemistry with glucagon antibodies and it was noted that the cells in the gut mucosa differed from islet -cells that produce glucagon (42)

Kontraindikationen Bei folgenden Erkrankungen ist die Einnahme von GLP-1-Rezeptoragonisten kontraindiziert: Diabetes mellitus Typ 1 oder diabetische Ketoazidose Niereninsuffizienz Akute Pankreatitis Diabetische Gastroparese Alternativen Als alternative Antidiabetika knnen folgende Wirkstoffklassen eingesetzt werden: Insulin(e) Biguanide (Metformin) Sulfonylharnstoffe/Glinide DPP-4-Inhibitoren (Gliptine) SGLT-2-Inhibitoren (Gliflozine) -Glucosidase-Hemmer Hinweise Hypoglykmie Patienten, die einen GLP-1-Rezeptoragonisten in Kombination mit Sulfonylharnstoffen/Gliniden oder Insulin erhalten, knnen ein erhhtes Risiko fr Hypoglykmien haben