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Altering the dosing frequency without medical supervision could lead to unpredictable blood levels, suboptimal efficacy, or unexpected side effects

Ann Intern Med (1980) 92(5):6139

Once opened, the pen remains stable for 28 days only if refrigerated
C.H.V.: conceptualization, data curation, formal analysis, validation, visualization, writing original draft, writing review and editing

as an add-on to metformin plus sitagliptin (0.5%-0.6% reduction)

One small study found no increased risk of major birth defects or miscarriage among women who took GLP-1 RAs during their first trimester
