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Novel Therapies in the Treatment of Congenital Hyperinsulinism

The nutrients most often affected include: Vitamin B12, essential for energy and nerve function Vitamin D, vital for bone health and immune support Iron, important for oxygen transport and energy metabolism Folate and zinc, both linked to cellular repair and metabolism Deficiencies in these areas can lead to fatigue, hair thinning, dry skin, or weakened immunity over time

The capacity of these drugs to increase insulin secretion and suppress glucagon release leads not only to better blood sugar control but also to a better cardiovascular profile, putting them in a favorable position in the treatment of type 2 diabetes

This lack of FDA approval means they haven't undergone the rigorous testing for safety, efficacy, and quality that regulated medications do
Further advantages (see Box 2 ) have led the American Diabetes Association (ADA) to recommend incretin mimetics as the first-choice injectable glucose-lowering therapy for type 2 diabetes, ahead of insulin (ADA, 2026)

GLP-3 Research: Mechanistic Rationale, Biomarkers, and Replication Practices Overview
