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Conflicts of interest There are no conflicts of interest

Considering serotonins peripheral effects on inhibiting thermogenesis in BAT and promoting lipid accumulation in WAT and liver, reducing peripheral serotonin levels could be an attractive attempt to ameliorate metabolic disorders
IPBN, lateral parabrachial nucleus

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Currently, semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) remain under patent protection, driving high branded costs
