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GLP-1 drugs are not just gut hormones, they cross the blood-brain barrier and bind to receptors in the mesolimbic system, which modulates reward signalling

In rare cases, side effects include pancreatitis and kidney injury

This show-stopping move should only be performed if the patient requires additional weight loss or glycemic control and has tolerated the previous dosing steps without any missteps

If you are a GLP-1 user If you are coming to the end of GLP-1 treatment, reducing medication, stopping treatment or trying to maintain weight loss after Ozempic, Wegovy or Mounjaro, The GLP-1 Legacy was written for this phase

Topiramate was also considered a stand-alone medication for obesity management as people who took it for other indications noted a decrease in appetite and weight-loss

Sub-therapeutic doses may provide insufficient pharmacological activity