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Rybelsus: Sometimes covered for diabetes, but rarely for weight loss

Its not willpower

This GLP-1 agonist works to reduce cravings and appetite while reducing blood sugar levels

However, individuals with obesity display high levels of circulating leptin, reflective of severe leptin resistance

Using a target trial emulation framework, researchers analyzed Truveta Data and compared adults with alcohol use disorder (AUD) and either type 2 diabetes or obesity who started a newer GLP-1 RA (semaglutide, tirzepatide) to similar individuals starting alternative medications

Oxytocin and naltrexone successfully treat hypothalamic obesity in a boy post-craniopharyngioma resection