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Furthermore, GLP-1 RA-mediated vasodilation can occur in states of low Nox-1/endothelin-1 and normal eNOS/guanylyl cyclase expression [117]

doi:10.3748/wjg.v25.i33.4904 48

Weight loss occurs through several mechanisms simultaneously

GLP-1 doses are typically started low and increased gradually, which is where Sheds format flexibility and provider guidance come in

Pharmacologic approaches to glycemic treatment: Standards of medical care in diabetes-2022

Patients should be aware of these potential unwanted effects and, to minimize loss of muscle mass, encouraged to participate in resistance exercises and increase protein intake [179]