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1 Of those, 135 letters were based on an FDA inspection (inspection-based warning letters), including 16 letters issued to clinical investigators or sponsors following inspections conducted as part of the FDAs Bioresearch Monitoring (BIMO) Program

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[4] [5] This occurs because tirzepatide's appetite-suppressing effectsmediated through hypothalamic pathways and delayed gastric emptyingresolve as drug levels decline