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227 The probiotics Bifidobacterium BGN4 and Lactobacillus fermentum HFY06 can also mediate the differentiation of T cells, inhibit the expression of IL-1 and COX2, promote the expression of the anti-inflammatory cytokine IL-10, enhance epithelial barrier function and reduce damage to the intestinal barrier by inhibiting the NF-B signaling pathway

In addition, destabilization of the spatial architecture of the islets of Langerhans and disruptions in intercellular communication are observed, particularly in the context of enhanced pro-inflammatory signaling and remodeling of the microenvironment (Karakose et al., 2024)

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