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The results of these analyses, after excluding RCTs with a primary endpoint other than body weight reduction (Nissen 2016

If your New Years Resolution is to lose some weight but youve been reluctant to try a glucagon-like peptide-1 (GLP-1) receptor agonist because they require weekly injections, you may be in luck

Despite the huge impact these drugs have had, caution is needed

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It can inhibit the signaling of the interleukin-4 (IL-4) and interleukin-13 (IL-13) pathways

Dysbiosis may increase DPP-4 activity, leading to faster breakdown of the GLP drugs and reducing their regulatory effects on glucose and appetite, resulting in increased hunger and cravings 4
